![]() ![]() Throughout the activity, students learn concepts such as fitness, natural selection, mutation, and phenotype. Students then watch the HHMI Video on pocket mice and answer discussion questions. q 0.5 Explanation: q2 (4/16) or 0.25, therefore q the square root of 0.25 or 0.5. Activity: Molecular Genetics of Color Mutations in Rock Pocket Mice. If there are 12 rock pocket mice with dark-colored fur and four with light-colored fur in a population, what is the value of q Remember that light-colored fur is recessive. Most rock pocket mice that live in areas covered by dark-colored lava rocks, however, are dark. Rock pocket mice that live in areas with a light-colored granite substrate are usually sandy in color. Students also graph the color differences at each location to show how the dark variation increased over time in response to an environmental change. The rock pocket mouse is a living example of Darwins process of natural selection. The rock pocket mouse is an excellent model organism for studying geographic variation in phenotype within a single species. Remember that fitness is defined by an organisms ability to survive and produce. (Cards can be printed and laminated for multiple uses.) Students collect data on the number of mice phenotypes in each location and develop a hypothesis about the order of the cards. Explain why a rock pocket mouses color influences its overall fitness. Students look at cards showing light and dark mice on different substrates. It has been simplified from the original activity so that it is suitable for beginner biology students. Michael Nachman, working in the field and lab, has quantified predation on rock pocket mice and identified adaptive changes in coat-color genes that allow the mice to travel under the radar of hungry predators. The mouse GFAP probe cross-hybridizes weakly at high stringency with genomic DNA from diverse eukaryotic species.This worksheet was modified from the HHMI Activity on color variation in the rock pocket mouse. Southern blot analysis indicates the existence of at most two genes encoding GFAP in the mouse genome. RNA blot transfer experiments using the cloned GFAP cDNA probe revealed a single GFAP mRNA species of 2.7 kilobases in mouse brain. Within the coding region, the data show extensive homology with other intermediate filament proteins, particularly in those regions predicted to be alpha-helical. Light-colored mice had a selective advantage because. However, volcanic eruptions have since spewed-out wide trails of black lava that weave right through the middle of. Ancestral pocket mice had light-colored coats that blended in with the regions rocks and sandy soil, keeping the mice hidden from their owl predators. The clone includes a long (1.4-kilobase) 3& amp #39 untranslated region. 'Rock pocket mice live in the deserts of the American southwest. Remember that fitness is defined by an organism’s ability to survive and produce offspring in its environment. Explain why a rock pocket mouse’s color influences its overall fitness. On the other hand, dark coat-colored rock pocket mouse populations have been found living on black, basaltic rock formations caused by geologic lava flows. The complete sequence of the cDNA insert in this clone is presented, encompassing 2.5 kilobases and specifying greater than 97% of the GFAP amino acid sequence. You may plot all of your data for both A and B on one bar graph or split A and B into two graphs. What specific trait did researchers study in this investigation Fur color, specifically melanism, is the trait they studied. They teach valuable lessons on mutation, selection, and convergent evolution, and tie together biochemistry, cell communication, and. The activities focus on the Mc1r gene, protein, and receptor. As you watch, record the following information. Ann Brokaw presents three BioInteractive resources she uses to support the short film Natural Selection and Adaptation. ![]() Natural Selection light-colored soil Note: individuals do not evolve adaptations to survive in their environment. B dominant MC1r allele for black color b recessive MC1r allele for light color 3. Watch the short film The Making of the Fittest: Natural Selection and Adaptation. making it easier for visual predators to prey on them light-colored desert soil 4. The library was screened using a GFAP-specific polyclonal antiserum a single bacterial colony expressing GFAP was identified. The mutation which results in a dark colour coat was present in the population before any volcanic activity could result in a dark soil, indicating that the. MAKING OF THE FITTEST: ROCK POCKET MOUSE ANSWER SHEET PROCEDURE 1. A clone encoding mouse glial fibrillary acidic protein (GFAP) was isolated from a cDNA library constructed so as to express the cloned sequences. ![]()
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